Bio-Analytics 3.1

Bio-Analytics Services : Bio-Analytics Services

Agenda : Agenda About Ocimum Ocimum Consulting Bio-Analytics Services

: About Ocimum Ocimum Consulting Bio-Analytics Services

Ocimum’s Products and Services : Bioinformatic Analysis Services Bioinformatics Analysis Tools (Toxico-)Genomic Reference Systems Ocimum’s Products and Services Affymetrix Agilent Illumina OciChip Genomic Data Generation Services Bio Research Design & Execution Lab, Sample & Data Management Data Analysis & Insights Biorepository Services QUTE™ modified and unmodified Oligos, Custom, catalog and platform Microarrays Microarray data analysis Sequence analysis Literature mining BioExpress™ - Genomic reference, ToxExpress™ - Toxicogenomic reference Genowiz™ - Gene expression analysis, Ascenta™ – Gene expression reference system, Genchek™ - Sequence analysis, Optgene™ - Gene optimization, Genesis™ - Data management and analysis Gene Expression: Data from tissue, RNA, blood SNP Genotyping: Whole genome DNA analysis Gene Sequencing Hybridization services miRNA, qRT-PCR Profiling for clinical trials Sample Storage Research Consumables Laboratory Information Management Systems Biotracker™ LIMS - For Genomics labs, Biotreacker™ for Biobanking (Also SaaS) Biotracker™ Lite – For generic labs (Also SaaS) Bio-Analytics IT Services Consulting Services Ocimum Consulting Application development Systems integration Testing as a service Support and maintenance services Build Operate and Transfer – BOT Solutions for life science industries

Ocimum’s Differentiated Approach : Ocimum’s Differentiated Approach More than 12 years experience in providing genomics products, services, custom applications Validated Genomic Reference Data used by most Big Pharma Genomic Services for Data Generation and Data Analysis Efficiencies of scale through integrated data generation, management, analysis and storage offerings Innovator in key genomic research areas with over 65 patents Presence in 3 continents enables efficient understanding of customer interactions Comprehensive Technical Expertise across US, India and Europe Manufacturing in US, Europe & India Facilities Cost savings via India Development Centre Development and round-the-clock customer support by highly capable staff with deep domain expertise Experience and Expertise Global Service Delivery Model

: About Ocimum Ocimum Consulting Bio-Analytics Services

Ocimum Consulting : Ocimum Consulting

Ocimum Consulting Value: Our People : Ocimum Consulting Value: Our People 20% - PhD 80% - Masters and other advanced degrees Education Team Composition 20% - Domain Experts 45% - Bioinformatics / Business analysts 35% - Statisticians Team Skill Base 25% - Mathematics and Statistics 35% - Medicine/Life science/ Chemistry 40% - Engineering / Computer Science 20%- Management

Ocimum Consulting Value: Quality Built-In : Ocimum Consulting Value: Quality Built-In Certification to the ISO 9001:2008 international standard for total quality management (TQM) systems is one way by which Ocimum demonstrates its commitment to quality assurance management, practices and principles Ocimum’s quality management system is independently assessed by the Det Norske Veritas(DNV) Quarterly and yearly assessments confirm that the requirements of the ISO9001:2008 standard are met or exceeded.

Ocimum Consulting Value: Experience : Ocimum Consulting Value: Experience Experience Over a decade of experience in successful delivery of sequence data, gene expression and genotyping data analysis for leading pharmaceutical, biotechnology, research institutes, and academic institutions Outstanding team with deep domain knowledge in statistics, molecular biology, bioinformatics, and IT skills We have optimized the process of data management and analysis by adopting industry best practices. These practices help us to deliver better solutions with quick turn around time. High quality data analysis using industry standard tools, latest and proven methodology Examples: Studying Chromosomal Copy Number Variations in Thyroid Cancer 45 thyroid cancer samples Total of 470 deletions, 860 copy-number gains. Affected pathways include MAPK signaling pathway, Wnt signaling pathway, Ubiquitin mediated proteolysis, focal adhesion, insulin signaling pathway and thyroid cancer pathway. Identification of bio-markers for chronic fatigue syndrome Statistical analysis was done using Partition Around Mediods (PAM) clustering and Silhouette analysis Identified 50 genes from microarray data, 15 SNPs from SNP data, and 9 factors from clinical data, as the markers

Ocimum Consulting Value: IP Security : Ocimum Consulting Value: IP Security Code for every project Separate secure network for client – different from Ocimum corporate network Work performed on dedicated machines with only client recommended software Data transfers on dedicated, secure network connection set up between the client site and Ocimum Encrypted data transfer between sites to ensure data security Access to data is limited to personnel with proper privileges and decryption keys The choice of encryption method (SSL, HTTPS or IPSec) made in consultation with the client

Ocimum Consulting Value: World-Class Customer Support : Website Live Help Phone Live Help Online Issue Tracking System (With automatic escalation) 24 X 5 Support (24 X 7 on fee basis) ISO 9001:2000 Processes On Site Support (When necessary & fees may apply) Web-based Bulletins Technical Documents FAQs Analysis Guides Training Videos Blogs Webinars Technical Training Online Sharing Tools On Site (When necessary & fees may apply) Ocimum Consulting Value: World-Class Customer Support

Awards and Accreditations : Awards and Accreditations ISO 9001:2008 certified quality firm Ocimum Selected as Top Bioinformatics Solutions Provider by ValueNotes/KnowGenix Report – January 2008 Product Innovation Award “OptgeneTM” by NASSCHOM. Awarded by President of India Ocimum Biosolutions in Deloitte Fast 500 Asia Pacific List – December 2009 Ranked 4th in Deloitte Technology Fast 50 India Program 2009 Inc. Magazine’s America’s Fastest Growing Private Companies

: About Ocimum Ocimum Consulting Bio-Analytics Services

Bio-Analytics : Bio-Analytics

Gene Expression Data Analysis : Gene Expression Data Analysis General Study Design Consultation Review of goals and hypotheses Power analysis Review of study design for confounding factors Microarray Analyses QC of Data/Outlier identification Review general trends within data – PCA, Clustering Differential Expression for Genes: t-test, SAM One way/two way ANOVA Pattern Matching GO and Pathway Analysis SNP Analyses Outlier identification (samples/SNPs) Hardy-Weinberg testing Structural Variation Copy Number Variation Loss-of-Heterozygosity Association Testing SNP Haplotype Regional TagSNPs Haplotype Estimation EM algorithm TagSNPs Predictive Modeling

Next Generation Sequence Analysis : Next Generation Sequence Analysis Sequencing Platforms Sanger method SOLiD Illumina 454 platforms   Next Generation Sequence Analysis De Novo Sequence Assembly Digital gene expression Transcriptome analysis  Methylation Studies

Other sequence based services : Other sequence based services Primers/ probe designing Probes for re-sequencing project For custom microarray chips siRNA and miRNA designing taqman probes Gene Optimization for GMO studies Marker selection and linkage analyses Population diversity and pedigree analyses Building annotations Data / Literature mining

Literature Mining : Literature Mining Gene models Annotations services Clinical relevancy studies Genome mining for association studies Integrated Data mining Text mining with High throughput data analysis Text mining along with pathways analysis

Algorithm Development : Algorithm Development Visualizations for a wide range of novel algorithms and techniques have been developed internally at Ocimum as part of our services and product development commitments. High throughput data Graph theory, SVM, suffix trees and hash mapping programs, etc. Predictive modeling Application of statistics in genomics and clinical studies.

Data Modeling : Data Modeling Data Modeling Methods Simple linear and logistic regression models. Support Vector Machines (SVM) Neural networks are used to build models that are data-driven and solution-specific. Customized models based on the data and forecast requirement. Examples In pharmacogenomics modeling has been used to predict disease status from gene expression profiles, disease association studies, and evaluation of candidate markers. In the agricultural industry predictive models have been used to forecast adaptability of a new crop variety, crop response to fertilizers, heritability of traits and QTL mapping.

Engagement Process : Engagement Process Flexible delivery / engagement models Project based delivery Time and material FTE based Outsource model On-site Off-shore Hybrid model Engagement process Non Disclosure Agreement for confidentiality Requirements analysis Project Kick start Iterative development process: Agile method QA/QC Final delivery Training

Representative Customer List : Representative Customer List ** Only customers who permitted usage of their names and logos

Thank YouFor more details and information please contactbioit@ocimumbio.com : Thank YouFor more details and information please contactbioit@ocimumbio.com