Slide 1 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 1 Online Bioscience Course for IT Professionals
Spring 2010
Slide 2 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 2 Class mechanics… View online video lecture every Monday (1-2 hour)
Comment on video lecture using website discussion
board
Attend the online Office Hour on Wednesday at 12 NOON
online using WizIQ.com and webcam
Online Final Exam given 7/7/2010
Slide 3 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 3 Lecture 6: Organs, tissues
and organisms
Slide 4 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 4 Take Homes: Multicellularity
II. Organs and tissues: structure and composition
III. Organs and tissues: genes determine structure
and composition
IV. Differentiation and development
V. Organisms
Slide 5 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 5 Dictyostelium is attracted to cAMP: http://www.dnatube.com/view_video.php?viewkey=217686ba124d7356686c
Slide 6 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 6 Dictyostelium moves toward cAMP
Using its cytoskeleton: http://dictybase.org/Multimedia/motility/motility.htm
Slide 7 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 7 Dictyostelium as a model for single cells “going”
multiclellular: http://en.wikipedia.org/wiki/Dictyostelium “stressed” founder
cell secretes cAMP,
inducing aggregation Streaming
spiral formation
Slide 8 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 8 Dictyostelium single cells assemble
into a multicellular “slug”: http://www.youtube.com/watch?v=518MhtVBJho
Slide 9 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 9 The evolutionary basis of
multicellularity: http://www.youtube.com/watch?v=JVqxyYBuI_U
Slide 10 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 10 Take Home I Organisms are collections of cells organized into tissues and organs… Multicellularity
Slide 11 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 11 The worm Caenorhabditis elegans-
700 cells make all of the tissues and
organs:
Slide 12 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 12 The cells that make-up tissues and
organs are specialized structurally
and compositionally:
Slide 13 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 13 Muscle structure and function: http://www.youtube.com/watch?v=ren_IQPOhJc
Slide 14 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 14 Three types of muscle: http://www.youtube.com/watch?v=PJDrR3sZPZU
Slide 15 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 15 Incredible human machine-
knowledge on muscle & bone
movement: http://www.youtube.com/watch?v=7Rzi7zYlWno
Slide 16 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 16 Take Home II Organisms are made-up of many cells, which are made-up of many specialized proteins organized into specialized structures according to function… Organs and tissues: structure and composition
Slide 17 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 17 Various types of actin proteins form
filaments in different types of
muscle:
Slide 18 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 18 Measuring RNA expression using
expressed Sequence Tags (ESTs):
Slide 19 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 19 Actin gene mRNA expression in
different types of muscle :
Slide 20 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 20 Measuring protein expression using
antibodies and tissue arrays:
Slide 21 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 21 Actin protein expression in different
muscle tissues:
Slide 22 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 22 Take Home III Differential expression of genes govern the protein structure, composition and thus function of cells in tissues and organs… Organs and tissues: genes determine structure and composition
Slide 23 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 23 Caenorhabditis elegans “fate map”:
Slide 24 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 24 Tagging a gene with GFP:
Slide 25 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 25 In the Beginning... there eas
C. elegans: http://www.youtube.com/watch?v=M6_0zjEzF6g
Slide 26 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 26 Fluorescent C. elegans
nervous system: http://www.youtube.com/watch?v=LuBF6S6qKas
Slide 27 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 27 Take Home IV Tissues and organs form from the egg through the processes of cellular differentiation and development, both of which are controlled by genes… Differentiation and development
Slide 28 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 28 Genes program development: http://www.youtube.com/watch?v=Oc4FAg2I_Z4
Slide 29 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 29 Using our knowledge about genes
and development to make a
“dinochicken”: http://www.youtube.com/watch?v=AeYhUUFDiF8
Slide 30 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 30 Take Home V The fundamental body plan and structure of an organism can be manipulated at the genetic level, and provides ways of testing ideas about evolution… Organisms
Slide 31 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 31 Next Week:
Physiology How the cells in tissues and organs function to make organisms work…
Slide 32 : 6/16/2010 Lecture 6: ORGANS TISSUES AND ORGANISMS 32 instructor
Mark E Minie PhD
mark@meminie.com