Slide 1 : 6/2/2010 Lecture 4:The Bacterial World 1 Online Bioscience Course for IT Professionals
Spring 2010
Slide 2 : 6/2/2010 Lecture 4:The Bacterial World 2 Class mechanics… View online video lecture every Monday (1-2 hour)
Comment on video lecture using website discussion
board
Attend the online Office Hour on Wednesday at 12 NOON
online using WizIQ.com and webcam
Online Final Exam given 7/7/2010
Slide 3 : 6/2/2010 Lecture 4:The Bacterial World 3 Lecture 4: The bacterial world
Slide 4 : 6/2/2010 Lecture 4:The Bacterial World 4 Take Homes: Bacteria have highly organized structures
II. The genome of bacteria
III. Bacterial cell movement
IV. Bacterial cell growth and metabolism
V. Bacterial films and the “microbiome”
Slide 5 : 6/2/2010 Lecture 4:The Bacterial World 5 The basic structure of a bacterium
(prokaryote):
Slide 6 : 6/2/2010 Lecture 4:The Bacterial World 6 Bacterial surface types:
Slide 7 : 6/2/2010 Lecture 4:The Bacterial World 7 Diffusion:
Slide 8 : 6/2/2010 Lecture 4:The Bacterial World 8 Active diffusion:
Slide 9 : 6/2/2010 Lecture 4:The Bacterial World 9 Bacterial types:
Slide 10 : 6/2/2010 Lecture 4:The Bacterial World 10 Bacterial conjugation: http://en.wikipedia.org/wiki/Bacterial_conjugation
Slide 11 : 6/2/2010 Lecture 4:The Bacterial World 11 Transformation: http://en.wikipedia.org/wiki/Transformation_%28genetics%29
Slide 12 : 6/2/2010 Lecture 4:The Bacterial World 12 The pGLO plasmid: http://en.wikipedia.org/wiki/PGLO
Slide 13 : 6/2/2010 Lecture 4:The Bacterial World 13 Bacteria use their flagella to move:
Slide 14 : 6/2/2010 Lecture 4:The Bacterial World 14 The structure, assembly and
function of the flagellum: http://www.youtube.com/watch?v=Ey7Emmddf7Y
Slide 15 : 6/2/2010 Lecture 4:The Bacterial World 15 Bacterial genome:
Slide 16 : 6/2/2010 Lecture 4:The Bacterial World 16 Bacterial genome-”gene music”: http://www.youtube.com/watch?v=G8ZAGi4ZlFI
Slide 17 : 6/2/2010 Lecture 4:The Bacterial World 17 Take Home I From their cell membranes and flagella down to the organization and replication of their DNA bacteria are highly organized and efficient structurally… Bacteria have highly organized structures
Slide 18 : 6/2/2010 Lecture 4:The Bacterial World 18 The flagellum “control circuit”:
Slide 19 : 6/2/2010 Lecture 4:The Bacterial World 19 In bacteria, genes that are part
of a “circuit” often are grouped
together in the genome:
Slide 20 : 6/2/2010 Lecture 4:The Bacterial World 20 The trp operon: http://www.youtube.com/watch?v=8aAYtMa3GFU
Slide 21 : 6/2/2010 Lecture 4:The Bacterial World 21 Take Home II The DNA genome of bacteria is very highly organized and efficient… The genome of bacteria
Slide 22 : 6/2/2010 Lecture 4:The Bacterial World 22 Bacterial growth: http://www.youtube.com/watch?v=gEwzDydciWc
Slide 23 : 6/2/2010 Lecture 4:The Bacterial World 23 DNA replication:
Slide 24 : 6/2/2010 Lecture 4:The Bacterial World 24 Bacterial motility: http://www.youtube.com/watch?v=zlFRJftA2bU
Slide 25 : 6/2/2010 Lecture 4:The Bacterial World 25 Bacterial motion and disease: http://www.youtube.com/watch?v=YZIg8FL4alA
Slide 26 : 6/2/2010 Lecture 4:The Bacterial World 26 Take Home III The mechanisms and controls of movement in bacteria are highly varied and play a role in disease… Bacterial cell movement
Slide 27 : 6/2/2010 Lecture 4:The Bacterial World 27 In prokaryotes, chromosomal DNA
replication starts from a single point
(an ori) and proceeds bi-directionally…
Slide 28 : 6/2/2010 Lecture 4:The Bacterial World 28 Semi-conservative DNA replication: http://www.dnatube.com/video/3028/Semiconservative-Replication
Slide 29 : 6/2/2010 Lecture 4:The Bacterial World 29 Glycolysis and fermentation: http://www.youtube.com/watch?v=UmfYnjHs8nk
Slide 30 : 6/2/2010 Lecture 4:The Bacterial World 30 Take Home IV Bacterial growth and metabolic pathways are well defined processes… Bacterial cell growth and metabolism
Slide 31 : 6/2/2010 Lecture 4:The Bacterial World 31 Biofilms I: http://en.wikipedia.org/wiki/Biofilms
Slide 32 : 6/2/2010 Lecture 4:The Bacterial World 32 Biofilms II: 5 stages of biofilm development. Stage 1, initial attachment; stage 2, irreversible attachment;
stage 3, maturation I; stage 4, maturation II; stage 5, dispersion. Each stage of development
in the diagram is paired with a photomicrograph of a developing P. aeruginosa biofilm.
All photomicrographs are shown to same scale.
Slide 33 : 6/2/2010 Lecture 4:The Bacterial World 33 Biofilms III: Stromatolites, proof of Life's Origin http://www.youtube.com/watch?v=4opsN_iQdEs
Slide 34 : 6/2/2010 Lecture 4:The Bacterial World 34 The human microbiome: http://www.youtube.com/watch?v=zzxEaGjXFZw
Slide 35 : 6/2/2010 Lecture 4:The Bacterial World 35 Take Home V Bacteria can form multicellular structures known as biofilms and also form complex symbiotic relation ships within higher organisms such as humans… Bacterial films and the “microbiome”
Slide 36 : 6/2/2010 Lecture 4:The Bacterial World 36 Next Week:
Higher cells How higher cells are structured and how they function…
Slide 37 : 6/2/2010 Lecture 4:The Bacterial World 37 instructor
Mark E Minie PhD
mark@meminie.com