Intro Chemistry of Fatty Acids and Triglyceride

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Introduction- Chemistry of Fatty Acids and Triglyceride

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Food Lipids : Food Lipids Professor David B. Min Department of Food Science and Technology The Ohio State University Columbus, Ohio 43210 Min.2@osu.edu http://class.fst.ohio-state.edu/fst821

DESCRIPTION : DESCRIPTION This course will cover an in-depth study of chemical and physical properties of edible fats and oils and the roles of their functional properties in food systems. Major topics covered will be chemistry of triglycerides, auto and thermal oxidation, antioxidants, chemical reactions in deep-fat frying, principles and application of polymorphism, interesterification and hydrogenation, fractionation of fats and oils, current instrumental analyses of lipids and biotechnology of fats and oils.

OBJECTIVES : OBJECTIVES To describe the relationship between the composition of tryglycerides and their chemical and physical properties. To describe the chemical reactions of auto and thermal oxidation of oil and the mechanisms of antioxidants. To describe the chemical mechanisms of hydrogenation and interesterification and their applications in fats and oils.

OBJECTIVES : OBJECTIVES To apply the physical and chemical methods to convert readily-available fats into tailor-made fats, that may be in greater demand or more desirable economically or nutritionally than the original fats. To describe the current instrumental and analytical methods as research tools in the fats and oils area. To describe the application of biotechnology to the modification and production of fats and oils.

GRADING : GRADING Exams (3) 60% Final Exam 30% Homework Assignments 10%

Course Schedule : Course Schedule Class Topics 1. Introduction and Classification of Lipid 2. Chemistry of Fatty Acids 3. Chemistry of Triglycerides 4. Chromatographic Analyses of Lipids 5. UV & IR Spectrometric Analyses 6. NMR Spectrometric Analyses 7. NMR Spectrometric Analyses 8. NMR and Mass Spectrometric Analyses 9. Mass Spectrometry 10. Mass Spectrometry

Course Schedule : Course Schedule Class Topics 11. Identification of Lipid Compounds by IR, NMR, MS 12. Examination 13. Lipid Oxidation - Chemistry of Oxygen 14. Free Radical Lipid Oxidation 15. Free Radical Lipid Oxidation 16. Singlet Oxygen Lipid Oxidation 17. Singlet Oxygen Lipid Oxidation 18. Singlet Oxygen Oxidation in Milk Products 19. Enzymatic Lipid Oxidation 20. Evaluation of Flavor Quality and Stability

Course Schedule : Course Schedule Class Topics 21. Chemical Reactions in Deep-Fat Frying Oils 22. Examination 23. Polymorphism 24. Application of Polymorphism in Foods 25. Interesterification 26. Interesterification 27. Hydrogenation 28. Hydrogenation 29. Examination

Reference Books : Reference Books 1. Flavor Chemistry of Fats and Oils by David B. Min and Thomas H. Smouse. American Oil Chemists' Society, Champaign, IL. 1985 2. Flavor Chemistry of Lipid Foods by David B. Min and Thomas H. Smouse. American Oil Chemists' Society, Champaign, IL. 1989 3. Food Lipids and Health by Richard E. McDonald and David B. Min. Marcel Dekker, Inc. New York, NY. 1996 4. Food Lipids by Casimir C. Akoh and David B. Min, Marcel Dekker, Inc. New York, NY.1998 5. Bailey's Industrial Oils and Fat Products by Y.H. Hui Wiley Interscience. New York, NY. 1996 6. Food Chemistry, 3rd Edition by O. Fennema, Marcel Dekker, Inc. New York, NY.1998

CLASSIFICATION OF LIPIDS : CLASSIFICATION OF LIPIDS

Triacylglycerol : Triacylglycerol

Simple Lipids : Simple Lipids A. Neutral fats - Triglycerides

Simple Lipids : Simple Lipids Waxes Fatty acids + Long chain alcohol    Beeswax (myricyl palmitate)     Spermaceti (cetyl palmitate)   O C 30 H 61 O C C 15 H 31 O C 16 H 33 O C C 15 H 31

Simple Lipids : Simple Lipids Cholesterol and Esters 17 C H C H 2 C H 3 C H 2 C H 2 C H C H 3 C H 3 5 3 6 HO Fatty acids +

Simple Lipids : Simple Lipids Retinol (Vitamin A1) and Esters

Simple Lipids : Simple Lipids Vitamin D and Esters    R = C8H17 in Vitamin D3 R = C9H17 in Vitamin D2 6 5 7 R H O H 2 C 8 fatty acids +

CHEMISTRY OF FATTY ACIDS : CHEMISTRY OF FATTY ACIDS

Classification and Structure-Saturated Fatty Acids : Classification and Structure-Saturated Fatty Acids Common Name Systematic Name Formula Butyric acid n-butanoic Caproic acid n-hexanoic Caprylic acid n-octanoic Capric acid n-decanoic Lauric acid n-dodecanoic

Slide19 : Common Name Systematic Name Formula Myristic acid n-tetradecanoic Palmitic acid n-hexadecanoic Stearic acid n-octadecanoic Arachidic acid n-eicosanoic Behenic acid n-docosanoic Lignoceric acid n-tetracosanoic

Monoethenoic Acid - Cis : Monoethenoic Acid - Cis 10 9 8 7 6 5 4 3 2 1 Δ 9, 10 - Octadecenoic acid 9 - Octadecenoic acid

Common Name of Fatty Acids : Common Name of Fatty Acids Common Name Systematic Name cis Myristoleic 9-tetradecenoic acid Palmitoleic 9-hexadecenoic acid Oleic 9-octadecenoic acid Vaccenic 11-octadecenoic acid Erucic 13-docosenoic acid

Polyethenoic Acids : Polyethenoic Acids Common Name Systematic Name Linoleic 9,12-octadecadienoic acid(cis,cis) or Octadeca-9,12-dienoic acid Linolenic 9,12,15-octadecatrienoic acid Arachidonic 5,8,11,14-eicosatetraenoic acid 4,8,12,16-eicosatetraenoic acid

Ethynoic Acids : Ethynoic Acids Common Name Systematic Name Tariric acid 6-octadecylinic acid

Hydroxy and Keto Acids : Hydroxy and Keto Acids Common Name Systematic Name Dihydroxystrearic 9,10-dihydroxyoctadecanoic Lactarinic 6-keto-octadecanoic

Cyclic Acids : Cyclic Acids Chaulmoogric acid 13-(2-cyclopentenyl) tridecanoic acid 4 5 1 3 2 C H 2 C H 2 C H ( C H 2 ) 12 C O H O C H C H

Triacylglycerol : Triacylglycerol

Fatty Acid Analysis : Fatty Acid Analysis 1. Method for oils : a. measure 5 - 15 mg oil into small vial. b. add 0.4 - 0.8 ml sodium methoxide. c. heat 60C for 50 - 60 min. d. add 0.4 - 0.8 ml saturated NaCl solution. e. extract with 0.4 ml petroleum ether. f. check derivertization (TLC-chloroform solvent). g. Gas Chromatography analysis

Slide28 : 2. For quantification : the same as above except a. add internal standard free fatty acid to oil. b. add equal volumes of sodium methoxide and BF3-methanol, 0.5 - 1.0 ml of each. c. heat 70 - 80C for 50 - 60 min. (if, after 20 min. of heating the sample is not dissolved, add more sodium methoxide and BF3-methanol). Fatty Acid Analysis

Slide29 : Disadvantages of Gas Chromatography Material has to be volatilized at 250°C without decomposition. R C OH CH 3 OH H 2 SO 4 O R C O CH 3 O CH 2 O C R CH O C R CH 2 O C R O O O CH 3 OH O R C O CH 3 CH 3 ONa Fatty Acids Methylester Reflux + 3 Volatile in Gas Chromatography Volatile in Gas Chromatography + +

Slide30 : Chromatogram of Fatty Acid Methyl Ester

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